The Endocannabinoid System

WHAT IS IT?

The Endocannabinoid System (ECS) is a self-regulating system of Cannabinoid Receptors that are located throughout your body. The ECS is involved in communicating with nearly every system of your body including the central nervous system, immune system and organs. This vital system is focused on supporting balance orhomeostasis in your body. CBD is one of the primary cannabinoids found in the Hemp Plant

 These cannabinoid receptors play a pivotal role in physiological processes such as mood, memory, pain and discomfort. There are 2 cannabinoid receptors - CB1 and CB2 that are located on cells throughout your body.

WHAT ARE CB1 AND CB2 RECEPTORS?

CB1 receptors are primarily located on nerve cells in the brain, spinal cord and the central nervous system. They are very abundant in the cerebellum, basal ganglia, and hippocampus. CB1 receptors have been found to play a role in-memory processing, motor regulation, discomfort and pain sensation, mood, and sleep. CB2 receptors are primarily found on cells in the immune system and its associated structures. When activated, they stimulate a response that fights inflammation, which can reduce pain and discomfort, and minimize damage to tissues. 

 

CB1 RECEPTORS

1) BRAIN / CNS / SPINAL CORD REGIONS / CEREBELLUM / BRAINSTEM (neocortex, periform cortex, hippocampus, amigoala)

2) THYROID (endocrine gland) 

3) UPPER AIRWAYS (of mammals) 

4) LIVER (kupffer cells - marophage immune cells, hepaticytes, liver-cell, hepatic stellate cells - fat storage cell)

 

5) ADRENALS / BASAL GANGLIA / THALAMUS / PITUITARY / HYPOTHALAMUS / OLFACTORY BULB (endocrine gland, globus pallidus, substantie nigra pars, reticulata, endocrine - brain link) 

 

6) OVARIES (gonads and endocrine gland) 

7) UTERUS (myomereium) 

8) PROSTRATE (epichelial and smooth muscle cells)

9) TESTES (gonads and endocrine gland, leydig cells and sperm cells) 

 

CB2 RECEPTORS

1) EYE (retinal pigment epithelial, RPE cells) 

2) STOMACH 

3) HEART 

4) PANCREAS 

5) DIGESTIVE SYSTEM 

6) BONES

 

BRAIN 

1) BASAL GANGLIA (movement) 

2) CERBAL CORTEX (higher cognitive function)

3) HYPOTHALAMUS (appetite) 

4) CEREBELLUM (movement) 

5) HIPPOCAMPUS (learning, memory, stress) 

6) MEDULLA (nausea and vomiting, chemoreceptor)

7) SPINAL CORD (peripheral sensation including discomfort)

 

HOW DO THESE RECEPTORS WORK?

Cannabinoids help coordinate and regulate how you feel and think by binding with the endocannabinoid system's CB1 and CB2 receptors. Cannabinoids are designed to link together with the cannabinoid receptors, like a key to a lock.

 

Linking activates the receiving neuron into action, triggering a set of events to pass along the message and carry out a variety of cellular responses needed for homeostasis and healthy functioning.

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